Intelligent Translational Medicine
FULLY AUTOMATED NGS PIPELINES:
GERMLINE, TUMOR/NORMAL (SOMATIC), RNA & CUSTOM
GenomeNext results contain pertinent biological information relieving the requirement for you to spend numerous hours interpreting results, saving valuable time and resources. By automating the annotation process and providing results that are reproducible, accurate and deterministic, GenomeNext’s analysis pipeline excels in its ability to support research and clinical studies.
GenomeNext’s Olympus Platform delivers clinically validated precision enabling more effective and accurate variant calling leading to the discovery of a more comprehensive and reproducible list of candidate biomarkers for further evaluation; a primary factor in selecting GenomeNext for sequence analysis and interpretation.
DATA MANAGEMENT & AUTOMATION
GenomeNext Automation Significantly Reduces Time, Cost & Operational Burden
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Seamless integration with Sequencer
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Automated streaming from sequencer to Olympus
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Automated demultiplexing & conversion
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Auto analysis generation
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No bioinformatic or manual intervention
SECURE GENOMIC DATA STORAGE
GenomeNext offers free compliant and secure storage for all your genomic data. Access your data anywhere in the world quickly and securely using our cloud based platform on any device. With no limit to the storage capacity of our solution, you can store as much data as you need, with the ability to manage downloads, deletion, and month over month storage. Run population scale genomics with no need to worry about storage capacity, security or cost. You control your data from any device.
Genomic Data Upload
Upload large data files directly to your account for analysis and storage using your web browser. If you are unable to utilize your network bandwidth to upload large data files, please contact us so we can provide you with a secure, custom upload solution that is right for you.
Secure & Compliant
GenomeNext follows industry best practices for data security and privacy as outlined by HIPPA, CLIA and the FDA. Best practices include rules for data encryption, data protection, data auditing, data backup, and disaster recovery.
PERFORMANCE
Whole
Genome
Analysis
30-50X Whole Genome ranging between 85GB-110GB will analyze in under 2.5 hours.
Whole
Exome
Analysis
50-100X Exome
ranging between 6-15GB
will analyze in under 1.5 hours.
Targetted
Panel
Analysis
100x Targetted Panel
ranging between 1GB – 5GB will analyze in under 30 minutes.
Clinically
Actionable
Results
Sensitivity
(True Positives)
99.99 %
99.99 %
Specificity
(True Negatives)
99.36 %
Diagnostic Effectiveness
(Diagnostic Index = Specificity + Sensitivity -1)
Accurate
Reproducible
Deterministic
CRITICAL FOR
CLINICAL DIAGNOSIS
IS YOUR SOLUTION TRULY
REPRODUCIBLE &
DETERMINISTIC?
GenomeNext’s proprietary technology enables NO DOWNSAMPLING and does not discard any sequence reads, therefore analysis results are exactly identical each and every run.
NO OTHER PIPELINE/COMPETITOR CAN DELIVER 100% REPRODUCIBLITY
Given a set of raw sequence data as input, every execution of the program produces identical variant calls and genotypes as the final output and regardless of the scale of parallelization, the final result is identical.
NO OTHER PIPELINE/COMPETITOR CAN DELIVER 100% DETERMINISM
Performance
Sample Case:
34 Clinical Exomes
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Turn-Key
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100% Automated from Sequencer to Clinical Results
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No Bioinformatic Intervention
VARIANT ANNOTATION, INTERPRETATION & REPORTING
VCF files are annotated with data from a suite of 22+ curated annotation databases (and private/proprietary databases as needed) and available for ACMG classification and pathology reporting including novel HGVS sequence ontology ranking addressing intergenic, coding and splice distances.
INTELLIGENT DISCOVERY ANALYTICS
FULLY AUTOMATED DISCOVERY ANALYTICS &
GENOME ASSOCIATION STUDIES
Discovery analytics and genome association studies can now be performed with ease. Using VCF and annotation data (and supporting clinical, demographic and biospecimen data if available) perform genomic pairwise and multivariate association studies for interpretation, discovery and clinical decision support. Our powerful platform delivers results in less than 1 hour.
Pairwise Comparison Studies analyzing the over-representation of variants and genes inclusive of demographic data such as:
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Alive v. Deceased
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Race, Gender, Age
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Tumor Stage
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Primary Therapy Outcome
POPULATION SCALE GENOMIC ANALYSIS
Do you need to analyze large sets of genomic data with the highest accuracy and results that are truly 100% reproducible?
The GenomeNext platform has been architected to scale as large as you need it, capable of supporting large population data sets.
No matter the size of your dataset, our solution can deliver the fastest population scale analysis without compromising on data quality or integrity.
We already did it.
Amazon Web Services and Intel challenged us to analyze the phase 3 dataset of the 1,000 Genomes project - and we did it in just 7 days.
We automated the entire process, taking 77 TB of data, that is over 5,000 genomic samples, and analyzed them in parallel delivering the highest accuracy in results. As a matter of fact, our results were reproducible.
GenomeNext discovered 4,000,000+ new variants that the 1KG Consortium missed.
CANCER CASE STUDY
GenomeNext analyzed 412 patient cases diagnosed with bladder cancer, incorporating proprietary patient follow-up and clinical outcomes to discover novel causative mutations impacting pathways and disease.
412 Bladder Cancer Cases
Tumor / Normal
8.82 Tb Data Analyzed < 45 Hours
Genotyper 1
Genotyper 2
Genotyper 3
Genotyper 4
Institutional
Dataset
Causative Candidate
Genes Discovered